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New research underscores benefits of gender-affirming hormones, rebutting anti-trans claims
(www.statnews.com)
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Exactly. Some things just can't be studied as part of a double blind RCT. For example, see: Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials
The paper is funny, but the authors are making a serious point. RCTs are great when they're possible, but just because they're not possible doesn't mean we can't gather strong evidence anyway.
Thank you for that paper, that's a great analogy honestly.