Sea of Stars - It reminded me a lot of older SNES RPGs from the past (looking at you, Chrono Trigger). I enjoyed this one a fair bit and looking forward to its release.
Enternights - The gameplay was interesting but pushing the whole horny thing a bit too much. The facial animations look like they could use a bit more work as they looked quite jarring/didn't seem to go with the rest of the game. The music was enjoyable though.
I think for me, the most painful experience is a tie -- one instance was Appendicitis (which was horrible) and the other instance was having one of our children without an epidural.