this post was submitted on 24 Jul 2026
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Is it safe?

I know estradiol pills fuck liver so I can fix this problem by switching to injections but I wonder if this is the case with progesterone?

I can't do the buffing stuff every night, sorry lol.

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[โ€“] hildegarde@lemmy.blahaj.zone 7 points 4 days ago (4 children)

Estradiol pills are processed in the liver. If you take them sublingually they're mostly not. You absorb more and it has a shorter half life, so may need to be dosed differently. Injections avoid the liver too.

The main concern I have heard about oral progesterone is that its much less effective that way. I don't think liver health is a major concern for oral progesterone. I'm getting HRT through my doctor, and I picked them very carefully to make sure I had one who was knowledgeable, and they've prescribed me oral progesterone. So it's probably fine.

If there are liver concerns I would like to know about it too!

[โ€“] TRAHR@sh.itjust.works 3 points 4 days ago

Not all pills can be taken sublingually, my ev Progynova is less effective if done so.

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