Transfem

Take all the oral versus rectal route stuff with a grain of salt. The studies thus far have been mostly done on cis women and were measuring blood levels directly, not results. The way that progesterone interacts with stuff like breast development is not super well understood either, nor are the levels at which good development can be expected. I read a study fairly recently that suggested that there was not a large difference in satisfaction rates for patients taking it orally versus rectally, both reported positive side effects. Empirically it is hard to accurately measure things like this.

I have tanner stage 5 breasts, and developed them to that stage before taking progesterone. My friend who takes hers rectally, and has for a couple years now, has tanner stage 4 breasts. Its anecdotal but I think is a good example of progesterone being less well understood.

Estradiol pills are processed in the liver. If you take them sublingually they're mostly not. You absorb more and it has a shorter half life, so may need to be dosed differently. Injections avoid the liver too.

The main concern I have heard about oral progesterone is that its much less effective that way. I don't think liver health is a major concern for oral progesterone. I'm getting HRT through my doctor, and I picked them very carefully to make sure I had one who was knowledgeable, and they've prescribed me oral progesterone. So it's probably fine.

If there are liver concerns I would like to know about it too!

oral prog long-term is safe, the main problem with is a dht backdoor, thru 5a reductase, BUTT also thru 5a reductase u will get neurosteroid - allopregnanolone, which can give mental side effects, since first-pass in liver will do a lot production to it, u want be sedated? u can try that, and huh thru liver the prog levels itself are also would be low, and lol progesterone itself can act as neurosteroid directly... https://en.wikipedia.org/wiki/Progesterone#Biological_activity

im very sensitive to any CNS shit, and i feel a lot the mental effects of progesterone, it rly rly did good things, cuz i take it rectally, maybe it only one med which helped me a lot without tolerance in 4 days

ALSO!!!! if u take oral prog, especially a lot, check interactions with your meds especially psych ones https://en.wikipedia.org/wiki/Progesterone_(medication)#Interactions

and yuh allopregnanolone producion can be numbed with finasteride and dutasteride(!!!, halflife 4–5 weeks, if u get sick on it, probably for long)

You can inject progesterone! Some suppliers sell estradiol and progesterone combined in a single vial.

What's all this about estradiol pills? I've been taking them for 6 years, should I be worried?