this post was submitted on 24 Jul 2026
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Is it safe?

I know estradiol pills fuck liver so I can fix this problem by switching to injections but I wonder if this is the case with progesterone?

I can't do the buffing stuff every night, sorry lol.

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[–] WillStealYourUsername@piefed.blahaj.zone 4 points 4 days ago* (last edited 4 days ago)

I did a reading of the pharmokokinetics article on prog a while back and it is indeed very complicated. I recommend people read up on it. I used transdermal prog for a while and it seems where you apply affects whether or not it actually gets into the blood, which is not the case for estradiol. But there's limited data for now