I combined Space Race (no purple or yellow science before a planetary science) and Keeping Your Hands Clean (No Biter Base kills without Artillery) with a 10x science cost. Almost ran out of iron before launching a space platform, had to import iron from space to keep things running. Also a Lazy Bastard run.

Doing that with Pyanodon's would be nuts, especially with the Biter Expansion changes comming in 2.1.