I'm not expert so wait for better responses but I would think it may vary by game. Maybe a dxvk.conf file to restrict the game to think you have less than 4gb, like 3.4 or something so it leaves overhead for other tasks.

Hopefully someone will come along and offer some past xp with bazzite, it may be worthwhile to mention a few games you plan to play just in case someone else plays them even if it's not in bazzite their distro settings may work the same performance wise