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I'd find that rather unlikely as humans producing alcohol at some levels, and thus the existence of alcoholics pretty much predates written history, and even wild animals etc... have tendencies to seek out fermenting fruits etc... obviously one of the biggest variables is the scale and availability of alchohol, people being able to buy shots of cheap vodka for less than the price of water at a gas station is certainly a more modern history development, and the modern problem where someone wanting to avoid alchohol altogether has their work cut out for them as in most states grocery stores and gas stations have it advertised and supplied.
But I'd still say based on the frequency of alchohol within stories, legends etc... which were intended to be relatable and understandable to the people of their time, I'd say at least a 5-15% alchoholism rate through pretty much all agricultural human civilization is a fairly safe estimate. and it looks like at least on some level, people with certain genes fell into that range more often than others.
admitted though the idea that we can read "throughout the history of those human genes existing" is silly. obviously we can only study peoples lives based on when the human genomes were recorded and study has begin.