I've only ever used regedit (on a linux distro) with wine tricks to try to get script mods to work for games. I think it was GTA, and skse and I don't think it fixed my issue I was just blindly following whatever I read on reddit might make it work. I'm so glad proton has matured it used to take me a couple days to figure out how to get one game to run on Linux. I hated setting up prefixes, and messing with winetricks when I barely knew what I needed.

I didn't look at the page but others are saying that might be the usecase and that checks out with me.

If you're on bazzite maybe this is a way for you to get access to tools on a immutable system? Though I think on bazzite you would just use steam tinkers launcher to access wine/proton tricks no? Its a flatpack so should be on discover store, and you can't install winetricks through CLI.