While this has changed, used to be you could look at the financials of a company and determine whether it was a reasonably good long-term investment, so you could pretty consistently build wealth with a diverse array of investments. With algorithmic trading down to the millisecond, much of this has gone out the window

Yeah, I was going to say something similar. What job you take, where you decide to live, friends you make all have a risk/reward element to them.

That being said I do believe there is a big difference between polymarket/prediction markets and stocks (or at least some stocks). Prediction markets is either betting on pure chance or against insider knowledge. Technically stocks should be seen as investing in a company (especially ones that pay dividends). Could a company run into hard times and lose you money, sure, but there is at least a bit more freely available information on that available to you.