I think there's a "SKSE for Linux" you can download so that you get it in a separate launcher, but renaming the executable to whatever the original one is will result in that newly renamed executable getting run when you press the play button. This approach works for Skyrim and Starfield but probably others as well.

SKSE works in Linux. I manually install each mod. It's a pain in the ass but I imagine still less of a pain in the ass than dealing with mod managers. I don't know who's teaching new programmers to make their side projects in such a way that it only works on windows but it's stupid and lame. It's not as bad as it used to be but there's always outliers that pop up such as Starfield xedit. You can put your ui in an opengl window. You can use python with wxwidgets. Java has good gui stuff. There are a multitude of ways to do ui besides Microsoft's bloated toolchain.