this post was submitted on 21 Jan 2025
119 points (98.4% liked)

Science

3371 readers
356 users here now

General discussions about "science" itself

Be sure to also check out these other Fediverse science communities:

https://lemmy.ml/c/science

https://beehaw.org/c/science

founded 2 years ago
MODERATORS
 

Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

top 14 comments
sorted by: hot top controversial new old
[–] some_guy@lemmy.sdf.org 2 points 44 minutes ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] workerONE@lemmy.world 7 points 3 hours ago

What about alcohol?

[–] Gullible@sh.itjust.works 37 points 8 hours ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] RobotToaster@mander.xyz 20 points 7 hours ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] __nobodynowhere@lemm.ee 3 points 7 hours ago (2 children)
[–] rickyrigatoni@lemm.ee 11 points 5 hours ago

The hat man cleans your brain for you.

[–] RobotToaster@mander.xyz 4 points 5 hours ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] anarchrist@lemmy.dbzer0.com 11 points 7 hours ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] metaStatic@kbin.earth 9 points 7 hours ago (1 children)
[–] MossyFeathers@pawb.social 7 points 6 hours ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] peoplebeproblems@midwest.social 4 points 7 hours ago (1 children)
[–] RvTV95XBeo@sh.itjust.works 2 points 2 hours ago

That usually helps me sleep better too

[–] Cephalotrocity@biglemmowski.win 2 points 6 hours ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] pelespirit@sh.itjust.works 5 points 6 hours ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater