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A cup of coffee for depression treatment has better results than microdosing (arstechnica.com)

submitted 8 months ago by adhd_traco@piefed.social to c/science@lemmy.world

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A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Åsberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression.

The study has not yet been published. But MindBio’s CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was “in front of the curve in microdosing research.”

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[-] rockSlayer@lemmy.blahaj.zone 26 points 8 months ago

Most people talking about microdosing are referring to shrooms (psilocybin), not LSD though

[-] Bademantel@lemmy.world 17 points 8 months ago

Really? I associate it with LSD. Isn't it more difficult with mushrooms as psilocybin concentration fluctuates? I guess you could extract it. Never really thought about it.

[-] nullroot@lemmy.world 6 points 8 months ago

Grind it up and put it in pills. The resulting pills will have approximately the same doses

[-] Beacon@fedia.io 5 points 8 months ago

The fluctuation doesn't make enough difference to switch between a microdose to a macrodose. But don't depend on the shake scraps at the bottom of the bag, because that stuff actually can vary wildly

[-] bobs_monkey@lemmy.zip 3 points 8 months ago

Ime the shroom powder is what can kick your ass the most

[-] JoeBigelow@lemmy.ca 2 points 8 months ago

I have accidentally BOOMED on the space dust at the bottom of the bag

[-] kabe@lemmy.world 12 points 8 months ago

Microdosing really just refers to taking sub-perceptual amounts of a given substance. It equally applies to things like THC and LSD as it does to shrooms.

[-] Beacon@fedia.io 3 points 8 months ago

Yeah microdosing LSD seems crazy to me because it lasts so much longer than shrooms. When I've heard of microdosing it's usually been referring to shrooms

[-] quips@slrpnk.net 24 points 8 months ago

Title is horrible. One study shows these benefits. Do not make empiric claims like that.

[-] adhd_traco@piefed.social 5 points 8 months ago

Usually places don't like editorialized titles, but here I really would just like to add [sensational title] or something at the end.

[-] Calfpupa@lemmy.ml 1 points 8 months ago

Do it

[-] TheReturnOfPEB@reddthat.com 18 points 8 months ago

I'd have to think that this report is looked unfavorably upon by the machine elves.

[-] PennyRoyal@sh.itjust.works 19 points 8 months ago

Maybe they should try macrodosing

[-] escapeVelocity@lemmy.ca 9 points 8 months ago

Fuckoff, I'll keep doing my own microdosing research.

For science OFC.

[-] sundray@lemmus.org 8 points 8 months ago

I like a nice placebo now and again, though.

[-] eleijeep@piefed.social 3 points 8 months ago

Alcoholic kind of mood
Lose my clothes, lose my lube
Cruising for a piece of fun
Looking out for number one
Different partner every night
So narcotic outta sight
What a gas, what a beautiful ass

And it all breaks down at the role reversal
Got the muse in my head she's universal
Spinnin' me round she's coming over me
And it all breaks down at the first rehearsal
Got the muse in my head she's universal
Spinnin' me round she's coming over me

[-] Unleaded8163@fedia.io 5 points 8 months ago

Why not both?

[-] escapeVelocity@lemmy.ca 3 points 8 months ago

I used to our a bit of shrooms in my coffee. It's actually tasting ok.

[-] blitzen@lemmy.ca 5 points 8 months ago* (last edited 8 months ago)

Isn’t a cup of coffee just microdosing with caffeine?

[-] HexadecimalSky@lemmy.world 5 points 8 months ago

and if its like how me and my friends make our coffee....more sugar than coffee. A mug of sugar keeps the depression away?

[-] i_love_FFT@jlai.lu 3 points 8 months ago

Yeah, coffee is definitely not a placebo

[-] webghost0101@sopuli.xyz 4 points 8 months ago

I somewhat assume you need a macro dose first. Your body needs to understand what the chemicals do.

Then when you microdose your body recognizes the chemicals and refreshed your subconscious memories about the state of mind.

Id love to see some science about microdosing in general, not just with psychedelics.

[-] quips@slrpnk.net 11 points 8 months ago* (last edited 8 months ago)

In my anecdotal experience, when I’ve done shrooms the depression benefits feel like they came not so much from the chemical itself but from the mindset it puts you in. That perspective, combined with the plastic state shrooms put you in has felt the most useful.

It allows you to reevaluate your life and gain perspective on it, while that plasticity actually lets those things stick.

When you microdose sure you might see some of those benefits, but you don’t really enter that altered state of mind where, imo, the real benefits come from.

This is why I think therapy guided sessions are likely the future of psychedelic treatment for mental illnesses like depression.