I switched over to Linux Mint a few days ago. While the game doesn't work 'out of the box', it doesn't take too much to get working. And boy does it work - it's loading up quicker than on Windows and seems to be more responsive while on a map too.

I only had one CTD, which was while testing one of the newer mods but I wasn't able to recreate it afterwards. I'll call that a significant win.