Considering the COVID pandemic is still mass infecting people (with somewhere around 1/10 people getting Long-COVID, and some percentage of those people being disabled long-term) and now it's leading to weakened immune systems and fungal infections, my guess is another mass health-disruption event is what we're on the brink of.
Or maybe mass homelessness and poverty. Does anyone remember that two-parter from Deep Space Nine where they go back in time with ghettos in San Francisco? Past Tense. It was set in 2024.