An AIO or air cooler aren't as impactful as the environment in my experience. Throw your computer in the corner of a room and that AIO ain't gonna help.
If you do go AIO, make sure you do it right.
Either case, good airflow design does wonders - air cooled or AIO.
I don't even know if I'm diagnosed. My psychiatrist started treating me for it and it worked wonders so.... Maybe? I've just never bothered asking.