I haven't used Guix system (as OS) but using it on top of Arch has been... Cool at least?
I can't speak for it's reliability or reproducibility that much since I haven't encountered issues yet. It's hard to grasp, and hard to setup, and needs a lot of time and network bandwidth but it's cool. I like adding my packages to a manifest so I know what is installed and when.
You can mininize them in their own workspace ( or keep them open in their own workspace) and you will get notifications for them still.