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submitted 2 days ago by arotrios@kbin.earth to c/science@lemmy.world

Abstract:

Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structure, and cognition despite high conservation of protein-coding genes. However, retroviral infections within host genomes have introduced numerous species-specific regulatory elements. Chimpanzees harbor lineage-specific PTERV1 endogenous retroviruses that are absent in humans, but their role in brain evolution has remained unclear. We performed an epigenomic analysis of PTERV1 insertions in chimpanzee neural organoids and found they are heavily DNA methylated, forming over 150 species-specific heterochromatin domains with the potential to influence gene regulation. We identified a chimpanzee-specific insertion on chromosome 19 that silences the long noncoding RNA LINC00662 through DNA methylation spreading. CRISPR-mediated deletion of this PTERV1 restored LINC00662 expression in chimpanzee induced pluripotent stem cells. We show that LINC00662, a human-specific transcript expressed during brain development, plays a role in neuronal maturation, axon outgrowth, and neural organoid development. These findings reveal a mechanism by which endogenous retroviral insertions contributed to human-chimpanzee brain divergence.

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[-] thevoidzero@lemmy.world 1 points 2 days ago

If it's not we got something from virus that helped us, and chimps got something that limited them. Then it's funnily possible for a global pandemic to make our whole population stupid. Normally evolution would work out and smarter population would do better, but for us it depends on which side has nukes. So ...

[-] froh42@lemmy.world 1 points 2 days ago* (last edited 2 days ago)

Then it's funnily possible for a global pandemic to make our whole population stupid.

Still, just from my gut feeling, this seems like a very convincing explanation to whatever is happening in the world in the last years.

this post was submitted on 27 Oct 2026
47 points (100.0% liked)

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