this post was submitted on 25 Dec 2023
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291
A Popular Sweetener Was Linked to Increased Anxiety in Generations of Mice (www.sciencealert.com)
submitted 11 months ago by pelespirit@sh.itjust.works to c/news@lemmy.world
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[–] capt_wolf@lemmy.world 5 points 11 months ago* (last edited 11 months ago) (1 children)

Guarantee the study also states that you have to consume an ungodly amount of it too...

News reports grab on to stuff like this all the time. Like what they did with safrole.

[–] smooth_tea@lemmy.world 8 points 11 months ago (2 children)

The article actually states how much. 15% of the daily recommended amount.

[–] Silverseren@kbin.social 7 points 11 months ago (2 children)

There's a daily recommended amount for mice? Or was that 15% of the recommended amount for humans, which would be massive for mice?

[–] someguy3@lemmy.ca 1 points 11 months ago (2 children)

15% of humans recommended amount. It's in the article.

[–] smooth_tea@lemmy.world 3 points 11 months ago (1 children)

Actually no, the keyword is equivalent, so adjusted for body weight.

[–] someguy3@lemmy.ca 2 points 11 months ago

Ah I think you're right.

[–] Silverseren@kbin.social 1 points 11 months ago (1 children)

So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.

Obviously it's more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That's a lot.

[–] smooth_tea@lemmy.world 2 points 11 months ago

I'm baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] smooth_tea@lemmy.world 1 points 11 months ago

It's the equivalent of the human daily dose. So adjusted for body weight. Loosely translated, it would be 15% of the daily recommended dose for mice.

[–] capt_wolf@lemmy.world 3 points 11 months ago (1 children)

I stand corrected! That's a ridiculously small amount!

[–] Silverseren@kbin.social 1 points 11 months ago (2 children)

Just in case you missed it, we discussed below that that's the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.

So you were right in the first place.

[–] smooth_tea@lemmy.world 4 points 11 months ago

No, it's the equivalent dose.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] papertowels@programming.dev 1 points 11 months ago

Can you cite your sources? This excerpt from the published article suggests you're wrong:

The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.