this post was submitted on 25 Dec 2023
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[–] echo64@lemmy.world 112 points 9 months ago (6 children)

1, it's aspartame

2, Mice aren't humans, and routinely, things that happen in mice do not happen in humans. It is not at all indicative of anything and can really only be used as a hint better than nothing for looking into similar effects in humans.

You don't need to change your diet, and you certainly don't need to replace it with sugar.

[–] LetterboxPancake@sh.itjust.works 74 points 9 months ago (1 children)

*But drinking a glass of water from time to time won't kill you either.

[–] elbarto777@lemmy.world 14 points 9 months ago (4 children)

Comment paid for Big Aspartame.

[–] Dkarma@lemmy.world 13 points 9 months ago (1 children)
[–] elbarto777@lemmy.world 2 points 9 months ago

I see the Nutrasweet Lobbyists Association is here too!

[–] Psychodelic@lemmy.world 8 points 9 months ago (1 children)

How much is Big Sugar paying you?

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[–] NikkiDimes@lemmy.world 8 points 9 months ago (1 children)

Big aspertame made that account 6 months ago, posted 1300 unrelated comments, just for this one moment...

[–] elbarto777@lemmy.world 3 points 9 months ago
[–] DragonTypeWyvern@literature.cafe 1 points 9 months ago

Considering the patent was held by Monsanto, and all the decades of concerns have been raised by independent researchers but shut down by lobbying...

Well, I mean, who can you trust to not hide that they're making poison if not Monsanto?

[–] Holymoly@lemmynsfw.com 9 points 9 months ago (19 children)

Removing all forms of added sugar would probably make everyone feel better. Even minimizing natural sugar intake.

Sugar is terrible, there’s no doubt about it. Artificial or otherwise.

[–] echo64@lemmy.world 18 points 9 months ago (9 children)

There's no research that indicates the currently used artificial sweeteners are bad for you.

[–] CaptainSpaceman@lemmy.world 9 points 9 months ago (2 children)

Theres mixed analysis over the decades, actually, and different groups have different conclusions.

https://www.everydayhealth.com/diet-nutrition/sweet-n-low-dangers-still-exist/

Overall, id say limiting added sugars (natural or artificial) is rpobably better for your health long term

[–] feedum_sneedson@lemmy.world 5 points 9 months ago (1 children)

Artificial sugars and sweeteners are, by and large, very different things. Aspartame isn't a sugar of any sort.

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[–] echo64@lemmy.world 3 points 9 months ago (8 children)

I want to be super clear if anyone finds this and thinks maybe...

No, there is no evidence of artificial sweeteners causing harm. There is no conspiracy, and after many many studies over decades, nothing has been found. If there had been, then the artificial sweeteners would have been banned like the ones you've never heard of because we all banned them for causing problems.

If you drink regular soda today, you should absolutely look at replacing that with a diet varient without sugar. From everything we have learned over decades, it's absolutely safe.

[–] ook_the_librarian@lemmy.world 6 points 9 months ago* (last edited 9 months ago) (3 children)

A few people are replying with links (of various relevance) but you are just saying "no" and claiming you're being "super clear". Some of the replies are directly contraindications of the claim:

If you drink regular soda today, you should absolutely look at replacing that with a diet varient without sugar.

Your counterpoint is saying they are "absolutely safe". I don't know whether you are right or wrong. It's not anywhere near my field, but I can say I don't find your rhetoric convincing.

Edit: I fucked up and pasted the wrong quote. I changed the quote to the one I meant.

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[–] smooth_tea@lemmy.world 1 points 9 months ago

Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880058/

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[–] visor841@lemmy.world 1 points 9 months ago (1 children)

Eh, IIRC there's research that if you eat incredible amounts it'll likely be bad for you. But it's a lot and the equivalent amount of sugar would be way way worse.

[–] msage@programming.dev 9 points 9 months ago (1 children)

Drinking too much water can kill you, too

[–] force@lemmy.world 3 points 9 months ago

i actually almost died from hyponatremia this year

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[–] Orbituary@lemmy.world 7 points 9 months ago (2 children)

Not to mention that the gene pool of these lab mice is super small. Source: my brother is a PhD biochemist and lectured me often on this shit when I said, "hey, look at this study!"

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[–] AkaBobHoward@lemmy.world 6 points 9 months ago

I am a relatively recent transplant from the red place, I can tell I ain't in Kansas anymore, actual good information being up voted so cool.

Aspartame is, because of all the claims against it, the single most studied food substance known, and it seems to somehow keep coming okay. There are a lot of studies with really bad methods that were a smear job attempt but science doing what it does they were labeled for what they are and disregarded. Is it possible to be allergic and a reaction to be anxiety sure, but that is not on the food.

[–] capt_wolf@lemmy.world 5 points 9 months ago* (last edited 9 months ago) (1 children)

Guarantee the study also states that you have to consume an ungodly amount of it too...

News reports grab on to stuff like this all the time. Like what they did with safrole.

[–] smooth_tea@lemmy.world 8 points 9 months ago (2 children)

The article actually states how much. 15% of the daily recommended amount.

[–] Silverseren@kbin.social 7 points 9 months ago (2 children)

There's a daily recommended amount for mice? Or was that 15% of the recommended amount for humans, which would be massive for mice?

[–] someguy3@lemmy.ca 1 points 9 months ago (2 children)

15% of humans recommended amount. It's in the article.

[–] smooth_tea@lemmy.world 3 points 9 months ago (1 children)

Actually no, the keyword is equivalent, so adjusted for body weight.

[–] someguy3@lemmy.ca 2 points 9 months ago

Ah I think you're right.

[–] Silverseren@kbin.social 1 points 9 months ago (1 children)

So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.

Obviously it's more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That's a lot.

[–] smooth_tea@lemmy.world 2 points 9 months ago

I'm baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] smooth_tea@lemmy.world 1 points 9 months ago

It's the equivalent of the human daily dose. So adjusted for body weight. Loosely translated, it would be 15% of the daily recommended dose for mice.

[–] capt_wolf@lemmy.world 3 points 9 months ago (1 children)

I stand corrected! That's a ridiculously small amount!

[–] Silverseren@kbin.social 1 points 9 months ago (2 children)

Just in case you missed it, we discussed below that that's the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.

So you were right in the first place.

[–] smooth_tea@lemmy.world 4 points 9 months ago

No, it's the equivalent dose.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] papertowels@programming.dev 1 points 9 months ago

Can you cite your sources? This excerpt from the published article suggests you're wrong:

The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.