this post was submitted on 11 Dec 2023
512 points (98.3% liked)

Science Memes

10759 readers
2372 users here now

Welcome to c/science_memes @ Mander.xyz!

A place for majestic STEMLORD peacocking, as well as memes about the realities of working in a lab.



Rules

  1. Don't throw mud. Behave like an intellectual and remember the human.
  2. Keep it rooted (on topic).
  3. No spam.
  4. Infographics welcome, get schooled.


Research Committee

Other Mander Communities

Science and Research

Biology and Life Sciences

Physical Sciences

Humanities and Social Sciences

Practical and Applied Sciences

Memes

Miscellaneous

founded 2 years ago
MODERATORS
 
top 34 comments
sorted by: hot top controversial new old
[–] Mr_Fish@lemmy.world 47 points 10 months ago (2 children)

If a women has starch masks on her body, does that mean she has been pargnet before.?

[–] dalekcaan@lemm.ee 15 points 10 months ago

how do u use a Luigi bored?

[–] Xttweaponttx@sh.itjust.works 10 points 10 months ago

Period question mark.

[–] Carvex@lemmy.world 39 points 10 months ago (2 children)
[–] DannyBoy@sh.itjust.works 17 points 10 months ago (2 children)
[–] NegativeLookBehind@kbin.social 19 points 10 months ago (1 children)
[–] general_kitten@sopuli.xyz 6 points 10 months ago (1 children)
[–] Linnce@lemmy.world 8 points 10 months ago
[–] Huschke@lemmy.world 5 points 10 months ago

Or am I OK?

[–] charonn0@startrek.website 21 points 10 months ago (1 children)
[–] ken_cleanairsystems@lemmy.sdf.org 14 points 10 months ago (1 children)

They need to do way instain mother who kill their babby

[–] pigup@lemmy.world 6 points 10 months ago* (last edited 10 months ago)

And these babby can no friggith back?!?

[–] pigup@lemmy.world 14 points 10 months ago (1 children)
[–] moog@lemm.ee 4 points 10 months ago (1 children)
[–] fjordbasa@lemmy.world 3 points 10 months ago* (last edited 10 months ago) (1 children)
[–] jaybone@lemmy.world 3 points 10 months ago
[–] JoBo@feddit.uk 11 points 10 months ago* (last edited 10 months ago)

I'm going to have to object. We don't use "false positive" and "false negative" as synonyms for Type I and Type II error because they're not the same thing. The difference is at the heart of the misuse of p-values by so many researchers, and the root of the so-called replication crisis.

Type I error is the risk of falsely concluding that the quantities being compared are meaningfully different when they are not, in fact, meaningfully different. Type II error is the risk of falsely concluding that they are essentially equivalent when they are not, in fact, essentially equivalent. Both are conditional probabilities; you can only get a Type I error when the things are, in truth, essentially equivalent and you can only get a Type II error when they are, in truth, meaningfully different. We define Type I and Type II errors as part of the design of a trial. We cannot calculate the risk of a false positive or a false negative without knowing the probability that the two things are meaningfully different.

This may be a little easier to follow with an example:

Let's say we have designed an RCT to compare two treatments with Type I error of 0.05 (95% confidence) and Type II error of 0.1 (90% power). Let's also say that this is the first large phase 3 trial of a promising drug and we know from experience with thousands of similar trials in this context that the new drug will turn out to be meaningfully different from control around 10% of the time.

So, in 1000 trials of this sort, 100 trials will be comparing drugs which are meaningfully different and we will get a false negative for 10 of them (because we only have 90% power). 900 trials will be comparing drugs which are essentially equivalent and we will get a false positive for 45 of them (because we only have 95% confidence).

The false positive rate is 45/135 (33.3%), nowhere near the 5% Type I error we designed the trial with.

Statisticians are awful at naming things. But there is a reason we don't give these error rates the nice, intuitive names you'd expect. Unfortunately we're also awful at explaining things properly, so the misunderstanding has persisted anyway.

This is a useful page which runs through much the same ideas as the paper linked above but in simpler terms: The p value and the base rate fallacy

And this paper tries to rescue p-values from oblivion by calling for 0.005 to replace the usual 0.05 threshold for alpha: Redefine statistical significance.

[–] blanketswithsmallpox@lemmy.world 7 points 10 months ago* (last edited 10 months ago) (1 children)

Nobody's going to mention that poor dude has ball cancer?

Fortuitous false positive.

False POSITIVE.

Negative false positive?

[–] GUBERNACULUM@lemmy.world 4 points 10 months ago

I feel like this joke is too nuanced for your average nonmedical person to get. But I dig it, thank you.

I hate that for a decade, I keep forgetting the differences or how to explain it. And this meme is how I finally learned it.

[–] vitamin@infosec.pub 6 points 10 months ago
[–] GBU_28@lemm.ee 6 points 10 months ago
[–] Damaskox@kbin.social 5 points 10 months ago

A YouTube video about this thing (I believe)

[–] RavenFellBlade@startrek.website 4 points 10 months ago

Dangerops prangent sex? will it hurt baby top of his head?

[–] theodewere@kbin.social 4 points 10 months ago

his whole world changed in an instant

[–] odium@programming.dev 4 points 10 months ago

Confusion matrices are beautiful

[–] shiveyarbles@beehaw.org 2 points 10 months ago

Ummm you're just fat

[–] RavenFellBlade@startrek.website 2 points 10 months ago
[–] Omega_Haxors@lemmy.ml 1 points 10 months ago

False Negative: [Doctor to Sonic] "You're not pregnant"

[–] EndHD@lemm.ee 1 points 10 months ago

better than any mnemonics the professors used back in uni

[–] RIP_Cheems@lemmy.world 1 points 10 months ago (1 children)
[–] Frozengyro@lemmy.world 7 points 10 months ago (1 children)
[–] RIP_Cheems@lemmy.world 1 points 10 months ago

It was a joke for the false negative